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Year : 2023  |  Volume : 28  |  Issue : 1  |  Page : 5

High amylase concentration in drainage liquid can early predict proximal and distal intestinal anastomotic leakages: A prospective observational study

1 Department of General, Digestive and Endocrine Surgery, Robert Debré University Hospital; University of Champagne-Ardenne, Reims, France
2 Department of Pharmacology and Toxicology, Robert Debreì University Hospital; University of Champagne-Ardenne, Reims, France
3 Department of Biochemistry, Robert Debreì University Hospital; University of Champagne-Ardenne, Reims, France

Correspondence Address:
Dr. Koceila Amroun
Department of General, Digestive and Endocrine Surgery, Robert Debre University Hospital, Rue Du General Koenig, Reims
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrms.jrms_273_21

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Background: Anastomotic leak (AL) is a serious complication in digestive surgery. Early diagnosis might allow clinicians to anticipate appropriate management. The aim of this study was to assess the predictive value of amylase concentration in drain fluid for the early diagnosis of digestive tract AL. Materials and Methods: Hundred and fourteen consecutive patients “at risk” of AL, in whom a flexible drainage was placed by surgeon's choice after digestive anastomosis were included. Patients with eso-gastric, bilio-digestive, and pancreatic anastomoses were excluded. Drain amylase measurement (DAM) was routinely performed on postoperative day (POD) 1, 3, 5–7. DAM values were compared between patients with postoperative AL versus patients without AL. A receiver-operating curve (ROC) with calculation of the areas under the ROC curves area under curves was performed and a cutoff value of DAM was calculated. Results: AL occurred in 25 patients (AL group) and 89 patients did not present AL (C group). The mean DAM was significantly higher in AL group versus C Group on POD 1, 3, and 5. A cutoff value of 307 IU/L predicted the occurrence of AL with a sensitivity and specificity of 91% and 100%, respectively. Positive and negative predictive values were 100% and 97.5%, respectively. Patients with AL had an elevated DAM prior to the appearance of any clinical signs of AL. Conclusion: High level DAM could accurately predict AL for proximal and distal digestive tract anastomoses. This simple, noninvasive, and low-cost method can accurately predict early AL and help physicians to perform appropriate imaging and treatment.

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