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Year : 2022  |  Volume : 27  |  Issue : 1  |  Page : 74

The efficacy of hemodialysis on paraquat poisoning mortality: A systematic review and meta-analysis

1 Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 School of Medicine, Isfahan Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
3 Clinical Informationist Research Group, Health Information Technology Research Center, Faculty of Medical Management and Information Sciences, Isfahan University, Medical Sciences, Isfahan, Iran
4 Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran
5 Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Emergency Medicine, Royal Adelaide Hospital, University of Adelaide, South Australia

Correspondence Address:
Dr. Alireza Rahimi
Medical Informatics Department, Health Information Research Center, Isfahan University Medical Sciences, Isfahan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrms.jrms_235_21

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Background: Paraquat (PQ) poisoning is a serious public health concern, especially in developing countries, due to its easy access and lack of awareness of potential harms. No effective treatment has been reported yet. Conventional hemodialysis (HD) is still used in many centers for excreting PQ or reducing acute kidney injury, but there is no consensus on its efficacy. Therefore, we aimed to review the HD efficacy in PQ poisoning mortality. Materials and Methods: We searched Web of Science, PubMed, Excerpta Medical Database, Google Scholar, Scopus, Cochrane, Web of Knowledge, Pro-Quest, ScienceDirect, Springer, Clinical Key, Scientific Information Database, Magiran, and Iran-doc, in publications before January 1, 2020. We compared patients who underwent HD (Group 1) with those who did not (Group 2). The outcome was considered mortality/survival. The data were analyzed by Comprehensive Meta-analysis Software. Results: This systematic review and meta-analysis included five studies with a combined total of 203 patients. The patients in the Group 1 had higher mortality than Group 2 (odds ratio, 2.84; 95% confidence interval: 1.22–6.64; P = 0.02). There was no evidence of publication bias (P value for Egger's test = 0.833). Conclusion: Although HD did not affect the survival of patients, other variables such as the amount of ingested PQ, poisoning severity, the time between PQ ingestion and the start of HD, duration, and times of HD sessions may influence the results regarding mortality.

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