| REVIEW ARTICLE |
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| Year : 2022 | Volume
: 27
| Issue : 1 | Page : 24 |
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Multiple sclerosis-related fatigue lacks a unified definition: A narrative review
Iman Adibi1, Mehdi Sanayei2, Farinaz Tabibian3, Neda Ramezani3, Ahmad Pourmohammadi3, Kiarash Azimzadeh3
1 Department of Neurology, School of Medicine, Isfahan University of Medical Sciences; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
3 Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence Address:
Dr. Iman Adibi
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jrms.jrms_1401_20
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Fatigue is the most common symptom in multiple sclerosis (MS). Although MS-related fatigue (MS-F) strongly affects quality of life and social performance of patients, there is currently a lack of knowledge about its pathophysiology, which in turns leads to poor objective diagnosis and management. Recent studies have attempted to explain potential etiologies as well as treatments for MS-F. However, it seems that without a consensus on its nature, these data could not provide a route to a successful approach. In this Article, we review definitions, epidemiology, risk factors and correlated comorbidities, pathophysiology, assessment methods, neuroimaging findings, and pharmacological and nonpharmacological treatments of MS-F. Further studies are warranted to define fatigue in MS patients more accurately, which could result in precise diagnosis and management.
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