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REVIEW ARTICLE
Year : 2022  |  Volume : 27  |  Issue : 1  |  Page : 24

Multiple sclerosis-related fatigue lacks a unified definition: A narrative review


1 Department of Neurology, School of Medicine, Isfahan University of Medical Sciences; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
3 Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Iman Adibi
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.jrms_1401_20

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Fatigue is the most common symptom in multiple sclerosis (MS). Although MS-related fatigue (MS-F) strongly affects quality of life and social performance of patients, there is currently a lack of knowledge about its pathophysiology, which in turns leads to poor objective diagnosis and management. Recent studies have attempted to explain potential etiologies as well as treatments for MS-F. However, it seems that without a consensus on its nature, these data could not provide a route to a successful approach. In this Article, we review definitions, epidemiology, risk factors and correlated comorbidities, pathophysiology, assessment methods, neuroimaging findings, and pharmacological and nonpharmacological treatments of MS-F. Further studies are warranted to define fatigue in MS patients more accurately, which could result in precise diagnosis and management.


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