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Prevalence of nephrocalcinosis in children with congenital adrenal hyperplasia
Yahya Madihi1, Neda Mostofizadeh2, Hossein Shamsipour Dehkordi3, Maryam Riahinezhad4, Silva Hovsepian2, Noushin Rostampour2, Elham Hashemi Dehkodi2, Mahryar Mehrkash5, Tooba Momen6, Mahin Hashemipour2
1 Metabolic Liver Disease Research Center, Department of Pediatric Nephrology, Imam Hossien Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2 Metabolic Liver Disease Research Center, Isfahan Endocrine and Metabolism Research Center, Imam Hossien Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Radiology, Imam Hossien Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Pediatric Nephrology, Imam Hossien Children's Hospital, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Imam Hossien Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence Address:
Dr. Neda Mostofizadeh
Metabolic Liver Disease Research Center, Isfahan Endocrine and Metabolism Research Center, Imam Hossien Children's Hospital, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jrms.jrms_872_21
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Background: We aimed to investigate the prevalence of nephrocalcinosis (NC) among children with diagnosed congenital adrenal hyperplasia (CAH). Our findings would be helpful for earlier diagnosis, management, and prevention of NC-related complications. Materials and Methods: In this cross-sectional study, children with CAH, aged <18 years old who were regularly referred for follow-up, were included. The information of the patients was extracted from their medical files, and they underwent renal ultrasonography for evaluation of the presence of NC. Results: From 120 studied patients with CAH, four patients (3.3%) had NC. The prevalence of NC was higher in males than females (P = 0.05). Mean age and age of CAH diagnosis had a trend to be lower in CAH patients with NC than those without. Regression analysis indicated significant association between NC and sex (P = 0.027, r = 2.24). Conclusion: The results of this study indicated a 3.3% prevalence rate of NC for children with CAH. NC had a trend to be more prevalent in male children with CAH. Though it was not significantly different but given that the mean age and age at diagnosis of CAH in children with CAH and NC was lower that CAH patients without NC, it is suggested that in patients with CAH and NC other factors such as genetic background or unknown disease related factors are associated with hypercalcemia and NC.
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