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ORIGINAL ARTICLE
Year : 2021  |  Volume : 26  |  Issue : 1  |  Page : 56

Changes in the diversity of local cervical bacteria in women with cervical cancer receiving antineoplastic treatment


1 Laboratory of Medical and Environmental Microbiology, Faculty of Medicine, Autonomous University of the State of Mexico, Toluca, Mexico
2 Clinical Research Division, National Institute of Cancerology, Mexico City, Mexico
3 Clinical Research Division, National Institute of Cancerology; Laboratory of Molecular Microbiology, National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico
4 Dean's Office of Health Sciences, Autonomous University of Guadalajara, Guadalajara, Mexico
5 Department of Biological Systems, Metropolitan Autonomous University-Xochimilco, Mexico City, Mexico

Correspondence Address:
Dr. Ninfa Ramirez.Duran
Av Paseo Tollocan, Esq. Jesus Carranza, 50180 Toluca
Mexico
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_757_19

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Background: Some studies show changes in the microbiota in people undergoing antineoplastic treatment. Currently, there is not enough evidence of this effect in the treatment of cervical cancer (CC). The objective was to determine changes in the diversity of local cervical bacteria in women with CC receiving chemotherapy, radiotherapy, and brachytherapy. Materials and Methods: A descriptive, longitudinal, and prospective study was conducted in 68 women with locally advanced CC with a treatment plan based on the administration of chemotherapy, external beam radiotherapy, and brachytherapy. Cervical-vaginal fluid samples were taken during antineoplastic treatment. The samples were used to isolate bacterial strains. The bacteria were identified at the molecular level by comparing sequences of the 16S ribosomal RNA gene. Results: The bacteria identified belonged to three phyla: Firmicutes, Proteobacteria, and Actinobacteria. Nine genera and 25 species of bacteria were identified. The most frequent species were Staphylococcus epidermidis, Corynebacterium amycolatum, and Enterococcus faecalis. There were statistically significant differences when comparing bacterial diversity found in the different stages of treatment (≤0.05). Bacterial diversity decreased as antineoplastic treatment progressed and increased at the end of therapy. Conclusion: Antineoplastic treatments generate changes in the diversity of local cervical bacterial communities of women with CC.


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