Effect of preeclampsia and premature rupture of membrane on neonatal birth weight and length by gestational age: A retrospective study in China

Nawsherwan; Abbas Khan; Sumaira Mubarik; Ghulam Nabi; Cuifang Fan; Suqing Wang

doi:10.4103/jrms.JRMS_131_19

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ORIGINAL ARTICLE

Year : 2021 | Volume : 26 | Issue : 1 | Page : 38

Effect of preeclampsia and premature rupture of membrane on neonatal birth weight and length by gestational age: A retrospective study in China

Nawsherwan¹, Abbas Khan², Sumaira Mubarik³, Ghulam Nabi⁴, Cuifang Fan⁵, Suqing Wang¹
¹ Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, Hubei, China
² Department of Dietetics and Nutritional Sciences, University of Sialkot, Pakistan
³ Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, Hubei, China
⁴ Key Laboratory of animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China
⁵ Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University, Wuhan Hubei, China

Correspondence Address:
Dr. Cuifang Fan
Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University, Wuhan 430 060, Hubei
China
Dr. Suqing Wang
Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuahan 430071, Hubei
China

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jrms.JRMS_131_19

Background: Preeclampsia (PE) and premature rupture of membrane (PROM) are considered significant risk factors for lower neonatal birth weight and birth length. However, very limited studies have reported the impact of PE and PROM on neonatal birth weight and birth length by gestational week. Therefore, we aimed to determine the effect of PE and PROM on neonatal birth weight and length by gestational age. Materials and Methods: A total of 9707 singleton neonates were selected for this study. All the data were collected and documented in the obstetric register by the trained nurses in the Gynecology and Obstetrics Department. Results: The neonatal mean birth weights and birth lengths were statistically significantly (P < 0.05) lowered among preeclamptic mothers compared to mothers without PE throughout the gestational age. Statistically significantly (P < 0.05) lowered mean birth weights and birth lengths were found among neonates born to mothers with PROM than among neonates born to mothers without PROM by all gestational weeks except for 32 weeks and 36 weeks. Moreover, in a multiple linear regression model, PE and PROM were significantly negatively associated with neonatal birth weights and birth lengths by almost all gestational weeks (β <0, P < 0.05). Conclusion: We concluded that after adjustment for covariates and confounding factors, PE and PROM had a significantly negative association with neonatal birth weights and birth lengths by all gestational weeks.

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