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ORIGINAL ARTICLE
Year : 2021  |  Volume : 26  |  Issue : 1  |  Page : 112

Serum level of Vitamin D is associated with COVID-19 mortality rate in hospitalized patients


1 Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
2 Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
3 Department of Infectious Diseases; Antimicrobial Resistant Research Center, Iran University of Medical Sciences, Tehran, Iran
4 Department of Pulmonology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
5 Department of Internal Medicine, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
6 Department of Social Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
7 Drug Discovery, Delivery and Patient Care (DDDPC) Theme, School of Life Sciences Pharmacy and Chemistry, Kingston University, London, United Kingdom
8 Department of Nephrology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
9 Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
10 Department of Interventional Radiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
11 Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Dr. Azadeh Laali
Antimicrobial Resistant Research Center, Department of Infectious Diseases, Iran University of Medical Sciences, Tehran
Iran
Prof. Mahin Jamshidi Makiani
Antimicrobial Resistant Research Center, Department of Infectious Diseases, Iran University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_1151_20

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Background: Due to widespread of coronavirus disease 2019 (COVID-19) infection, identification of its risk factors and clinical characteristics are important. The aim of the present study was to assess Vitamin D levels in individuals with severe acute respiratory syndrome coronavirus-19 infection and to report on its potential as a predictive marker. Materials and Methods: All patients, diagnosed with COVID-19 infection from February 16 to March 21, 2020, and referred to Firoozgar Hospital, Tehran, Iran, were enrolled in this study. Vitamin D analysis was undertaken on patient serum samples using a commercial kit (Pars Azmoon Co., Tehran, Iran). SPSS v. 22 was used for statistical analysis. Results: Vitamin D serum concentration was analyzed in a total of 317 patients whose mean age ± standard deviation was 62.05 ± 15 years and with 62.5% being male. A significant association of Vitamin D level and death was observed. Higher levels of serum Vitamin D had protection against death (odds ratio = 0.955 [95% confidence interval = 0.923–0.988], P = 0.008). Conclusion: As a preliminary study in the Iranian population who suffered COVID-19 disease, we identified that Vitamin D deficiency was associated with a higher death rate and intensive care unit admission.


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