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SHORT COMMUNICATION
Year : 2021  |  Volume : 26  |  Issue : 1  |  Page : 111

How is insulin-like growth factor-1 correlated with retinopathy of prematurity?


1 Department of Neonatology and Perinatology, Zanjan University of Medical Science, Zanjan, Iran
2 Retin Specialist, Zanjan University of Medical Science, Zanjan, Iran
3 Neonatal Health Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Pediatrics, Zanjan University of Medical Science, Zanjan, Iran
5 Statistics and Epidemiology, Department of Social Medicine, Medical School, Zanjan university of Medical Science, Zanjan, Iran
6 Department of Pathology, Zanjan University of Medical Science, Zanjan, Iran

Correspondence Address:
Dr. Naeeme Taslimi Taleghani
Neonatal Health Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Shariati Avenue, Tehran 15468-155514
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_501_20

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Background: Evaluation of insulin-like growth factor-1 (IGF-1) association with retinopathy of prematurity (ROP) is our object. Materials and Methods: This study was conducted on IGF-1 levels of 40 neonates <34 weeks gestational age and 2000 g at 1st week and 4–6 weeks after birth. All participants were evaluated for ROP after 31 weeks of gestation. Results: IGF-1 levels showed a significant difference between neonates ≤1500 and 1500–2000 g (1 and 4–6 weeks, P = 0.008, P = 0.039, respectively). No significant association was found between IGF-1 and ROP. Conclusion: Finding a meaningful association between IGF-1 and ROP requires consideration of factors affecting the IGF-1.


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