| REVIEW ARTICLE |
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| Year : 2018 | Volume
: 23
| Issue : 1 | Page : 7 |
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Role of granulocyte colony-stimulating factor in human reproduction
Maryam Eftekhar1, Elham Naghshineh2, Parisa Khani1
1 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd; Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence Address:
Dr. Elham Naghshineh
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd; Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jrms.JRMS_628_17
Clinical trial registration IRCT2016071628945N1
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As new research reveals, granulocyte colony-stimulating factor (G-CSF) plays an effective role in pregnancy success, considering that it not only affects the embryo implantation and ovarian function but also it promotes endometrial thickening and improves the pathophysiology of endometriosis, which all fundamentally lead to reducing pregnancy loss. In this review, we focus on the role of G-CSF in human reproduction. We summarized its role in ovulation, luteinized unruptured follicle syndrome, poor responders, improving repeated in vitro fertilization failure, endometrial receptivity and treatment of thin endometrium, and recurrent spontaneous abortion.
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